The Pittsburgh Pirates (51-71) and the Chicago Cubs (68-52) begin a three-game series between NL Central rivals on Friday afternoon. Pittsburgh is in a massive slump, as the Pirates have lost six straight games. The Brewers beat the Pirates 12-5 on Wednesday. The Cubs lost 2-1 at the hands of the Toronto Blue Jays yesterday. Colin Rea (9-5, 4.09 ERA) starts for Chicago. Pittsburgh has yet to announce its starter.
First pitch from Wrigley Field is set for 2:20 p.m. ET. The Cubs are the -202 money-line favorites in the latest Pirates vs. Cubs odds from FanDuel Sportsbook, while the over/under for total runs scored is 9. Before making any Pirates vs. Cubs picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 21 of the 2025 MLB season a profitable 31-23 on top-rated MLB money-line picks. It has excelled making home run prop picks this season, returning nearly 60 units of profit. Anybody following its MLB betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has set its sights on Pirates vs. Cubs and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Pirates vs. Cubs, and new users can also target the DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:
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Pirates vs. Cubs money line |
Cubs -202, Pirates +166 at FanDuel |
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Pirates vs. Cubs over/under |
9 runs |
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Pirates vs. Cubs run line |
Chicago -1.5 (-102) |
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Pirates vs. Cubs picks |
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Pirates vs. Cubs streaming |
Fubo (Try for free) |
Why the Pirates can win
Right fielder Bryan Reynolds leads the team in batting average (.247), RBI (61) and hits (111). He has recorded a hit in four straight games, including a 3-for-4 outing on Wednesday against the Brewers. Reynolds had two home runs, five runs driven in and two runs scored.
Outfielder Andrew McCutchen is batting .243 with 11 home runs and 40 RBI. In addition, in his career versus Chicago, he has 206 hits, 32 home runs and 114 runs scored. Pittsburgh owns a 26-22 run line record as the away underdog. See which team to back at SportsLine.
Why the Cubs can win
Right fielder Seiya Suzuki has been stellar all season long, as he’s tied for 10th in the MLB in home runs (27) and eighth in RBI (85). In Wednesday’s defeat to the Blue Jays, Suzuki went 1-of-3 with one run driven in.
Center fielder Pete Crow-Armstrong has been another reliable force for this club. In 2025, he’s tied for 10th in the league in home runs (27) along with 78 RBI and a .254 batting average. Following a loss, Chicago has a 34-17 run line record. They are also 36-20 as the home team. See which team to back at SportsLine.
How to make Pirates vs. Cubs picks
SportsLine’s model is leaning Under on the total, projecting 8.6 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks.
So who wins Pirates vs. Cubs, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.