It’s Thursday, August 21 and the Giants (61-66) are in San Diego to take on the Padres (71-56). Justin Verlander is slated to take the mound for San Francisco against Dylan Cease for San Diego.
San Diego goes for the series win after a 8-1 victory on Wednesday to follow up a 5-1 win. The Padres’ two wins snapped a four-game losing skid the team had going whereas the Giants are 2-9 over the last 11 games and 2-2 in the past four.
Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Giants at Padres
- Date: Thursday, August 21, 2025
- Time: 4:10PM EST
- Site: Petco Park
- City: San Diego, CA
- Network/Streaming: NBCSBA, SDPA
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Giants at the Padres
The latest odds as of Thursday:
- Moneyline: Giants (+145), Padres (-173)
- Spread: Padres -1.5
- Total: 8.0 runs
Probable starting pitchers for Giants at Padres
- Pitching matchup for August 21, 2025: Justin Verlander vs. Dylan Cease
- Giants: Justin Verlander, (1-9, 4.23 ERA)
Last outing: 0.00 ERA, 0 Earned Runs Allowed, 2 Hits Allowed, 0 Walks, and 8 Strikeouts - Padres: Dylan Cease, (5-11, 4.61 ERA)
Last outing: 8.10 ERA, 3 Earned Runs Allowed, 2 Hits Allowed, 6 Walks, and 2 Strikeouts
- Giants: Justin Verlander, (1-9, 4.23 ERA)
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Expert picks & predictions for tonight’s game between the Giants and the Padres
Rotoworld Best Bet
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Thursday’s game between the Giants and the Padres:
- Moneyline: NBC Sports Bet is recommending a play on the San Diego Padres on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the San Francisco Giants at +1.5.
- Total: NBC Sports Bet is staying away from a play on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Giants at Padres
- San Diego is 9-3 versus San Francisco this season
- The Giants are 2-9 in the last 11 games
- The Padres are 2-4 in the last 6 games
- The Padres have won 4 of their last 5 home games against teams with losing records
- The Under is 48-37-5 in the Padres’ matchups against National League teams this season
- The Giants have failed to cover the Run Line in 4 of their last 5 road games against the Padres
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
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- Jay Croucher (@croucherJD)
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- Trysta Krick (@Trysta_Krick)