Steelers vs. Patriots odds, start time: Everything you need to crush your 2025 NFL Week 3 picks

The Pittsburgh Steelers (1-1) and the New England Patriots (1-1) square off in an AFC showdown in Week 3. The Steelers beat the Jets in Week 1 but lost 31-17 to the Seattle Seahawks in Week 2. It was the opposite for New England, which lost its opener before defeating the Miami Dolphins 33-27 in Week 2. Alex Highsmith (knee) is out for the Steelers, and Christian Gonzalez (hamstring) is questionable with New England. 

Kickoff is set for 1 p.m. ET from Gillette Stadium in Foxborough. The Steelers are favored by 1.5 points in the latest Steelers vs. Patriots odds at DraftKings Sportsbook, while the over/under for total points scored is 44.5. Before making any Patriots vs. Steelers picks, make sure you check out the NFL picks from the SportsLine Projection Model.

New users can also target the all-new DraftKings promo code, which offers $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 37-17 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has zeroed in on Steelers vs. Patriots. Here are several NFL odds and betting lines for Patriots vs. Steelers:

Here are SportsLine Projection Model’s best bets for Steelers vs. Patriots:

• Steelers -1.5
• Under 44.5 points

Steelers -1.5

In 2024, the Steelers went 5-3 ATS as the favorite and 7-4 ATS in non-division games. The Steelers have a lot of veterans on the team, which should be an advantage on the road against the Patriots. Drake Maye is 2-5 in his career at home and has been under duress this season, getting sacked seven times already. The model projects that Pittsburgh (-1.5) will cover the spread in 61% of simulations on Sunday. 

Under 44.5 points

The Steelers have failed to record more than 271 total yards in a game this season and scored just 17 points at home last week against the Seahawks. They went 5-of-15 on third down and averaged just 4.5 yards per play. New England’s offense has been inconsistent, tallying 13 points in Week 1. Both teams have allowed pressure to get home, each giving up seven sacks through two games. The Under hits in 57% of simulations, according to the SportsLine Projection Model.

Want more Week 3 NFL picks?

You’ve seen the model’s Week 3 NFL best bets. Now, get against the spread, total and money-line picks for every Week 3 NFL game here, all from the model that’s simulated every game 10,000 times.