Jason Logan breaks down his favorite Week 5 NFL odds that you should act on quickly, or wait until later in the week!
Photo By – Imagn Images. Kansas City Chiefs quarterback Patrick Mahomes (15) hands the ball off.
Welcome to October football.
The fate of NFL bettors can change just as quickly as the autumn leaves, with a month’s worth of data points now coursing through the oddsmakers’ NFL power ratings.
Getting the best of your bookie often means getting the best of the number. That’s where I come in.
I put my finger on the pulse of the NFL gambling markets, predicting line movement and weighing public perception. I highlight some spreads and totals to add to your NFL picks right now and put a pin in some lines to bet later in the week.
Here are my “Bet Now, Bet Later” NFL Week 5 odds.
NFL predictions: Week 5 bet now, bet later picks
- Chiefs at Jaguars: Chiefs -3
- Coming Soon: Bet Later
- Raiders at Colts (Over 48.5): Bet Now
- Coming Soon: Bet Later
Kansas City Chiefs (-3) at Jaguars: Bet Now
To modify a quote from “John Wick”: Yeah, I’m thinking KC is back!
The Kansas City Chiefs let the AFC know that they’re still the conference champs with a shit kicking of the Baltimore Ravens in Week 4.
Kansas City’s defense choked out the Ravens on crucial downs (Baltimore 4 for 14 on third/fourth down) and forced two takeaways. The 37-20 final isn’t even a good indicator as to how one-sided this one was, as Baltimore put up some positives in garbage time.
After a challenging start to 2025, the Chiefs have looked like Super Bowl contenders the past six quarters and now travel to Florida for a Monday Night Football matchup with the Jacksonville Jaguars.
Jacksonville is coming off a weird win over San Francisco, in which it needed four takeaways and a punt return touchdown to squeak out a 26-21 victory. The Jags were outgained by the Niners, gave up 22 first downs, allowed an average of 6.2 yards per play, and were penalized for 90 yards on 12 flags. Yet, they enter Week 5 at 3-1 SU.
This is a notable coaching mismatch with Liam Coen and Anthony Campanile going up against Andy Reid and Steve Spagnuolo. Books opened Kansas City as a 3-point road favorite, and I’m snatching this key number up now before the nasty hook shows up later in the week.
Best odds to bet Chiefs -3 right now
Team at Team: Bet Later
Coming Soon!
Covers NFL betting tools
Las Vegas Raiders at Indianapolis Colts (Over 48.5): Bet Now
The Indianapolis Colts left plenty of points on the table in La-La Land on Sunday. More specifically, Adonai Mitchell did.
Indianapolis’ WR fumbled away an impressive catch-and-run TD at the goal line, which resulted in a touchback. Then he wiped a 53-yard Jonathan Taylor touchdown run from existence with a holding call.
Indianapolis lost 27-20, and the final score stayed Under the total of 50 points. Despite those blunders and three turnovers, the Colts still hung 333 yards on a very good Rams defense on the road.
Indy gets to come back to Lucas Oil in Week 5 for a potential shootout with the Silver and Black. Las Vegas is staggering after Chicago blocked a would-be game-winning field goal in Week 4. The Raiders amassed 357 yards but coughed the ball up four times, losing 25-24.
This total opened at 48.5 points, but the look-ahead number was 49.5 last week. You have two offenses that can hit big plays, both with the pass and the run, and they’re playing on the fast indoor track in Indy. I could see this climbing to 50 or higher later in the week.
Best odds to bet Raiders vs Colts Over 48.5 right now
Team at Team: Bet Later
Coming soon!
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.