NFC West rivals the San Francisco 49ers and the L.A. Rams are in a heated battle for first place in their division, with both teams, along with the Seattle Seahawks, currently heading into Week 5 with a 3-1 record. The 49ers will head to SoFi Stadium for a Thursday Night Football game against the Rams where the current tie for first will be broken. Rams QB Matthew Stafford, who suffered a back injury that threatened his participation earlier this season, hasn’t let it stop him from passing his 385th career touchdown this past weekend. 49ers quarterback Brock Purdy, who dealt with an injured toe in recent weeks, is not confirmed to play in Thursday’s game; if he’s on the injured list, Mac Jones will start.
The 49ers vs. Rams game will stream live nationally on Amazon Prime Video tonight at 8:15 p.m. ET. Keep reading to find out what you need to know about Thursday’s game, and the rest of the Week 5 schedule.
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How to watch the San Francisco 49ers vs. Los Angeles Rams game
Date: Thursday, Oct. 2, 2025
Coverage start time: 7 p.m. ET
Kickoff time: 8:15 p.m. ET/5:15 p.m. PT
Game: San Francisco 49ers vs. L.A. Rams
Location: SoFi Stadium, Los Angeles
Streaming: Prime Video
What channel is the 49ers vs. Rams game on?
The 49ers visit the Rams tonight, Oct. 2, for the next Thursday Night Football game of the season, streaming on Amazon’s Prime Video.
Amazon Prime Video is the exclusive home for the NFL’s Thursday Night Football games, including tonight’s game. On top of Amazon Prime Video, an Amazon Prime subscription includes free shipping, exclusive deals, access to the Prime Day sales events, Amazon Music, a year of free GrubHub+ and more.
A standard Amazon Prime subscription is $15 monthly or $139 annually, but discounts are available for students and those on qualified government assistance. You can try Amazon Prime free for 30 days. You can also just subscribe directly to Prime Video and forego all the other Prime Benefits. A Prime Video subscription costs $9 monthly.
NFL Week 5 schedule:
All times Eastern.
Thursday, Oct. 2, 2025
Sunday, Oct. 5, 2025
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Dallas Cowboys vs. New York Jets: 1:00 p.m. (FOX)
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Denver Broncos vs. Philadelphia Eagles: 1:00 p.m.(CBS)
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Houston Texans vs. Baltimore Ravens: 1:00 p.m. (CBS)
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Miami Dolphins vs. Carolina Panthers: 1:00 p.m. (FOX)
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Las Vegas Raiders vs. Indianapolis Colts: 1:00 p.m. (FOX)
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New York Giants vs. New Orleans Saints: 1:00 p.m. (CBS)
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Tennessee Titans vs. Arizona Cardinals: 4:05 p.m.(CBS)
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Tampa Bay Buccaneers vs. Seattle Seahawks: 4:05 p.m.(CBS)
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Detroit Lions vs. Cincinnati Bengals 4:25 p.m. (FOX)
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Washington Commanders vs. L.A. Chargers: 4:25 p.m. (FOX)
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New England Patriots vs. Buffalo Bills: 8:20 p.m. (NBC)