The Week 15 NFL schedule features 16 more games, including several with potential playoff ramifications. One such game is an AFC East battle between the Buffalo Bills (9-4) and New England Patriots (11-2). Buffalo is favored by 1.5 points as Josh Allen and the Bills take on Drake Maye and the Patriots. Buffalo is on a two-game winning streak, while New England has won 10 straight.
Another key matchup is between two NFC contenders as the Detroit Lions (8-5) clash with the Los Angeles Rams (10-3). The Lions are battling for a playoff spot, while the Rams are seeking to retain the No. 1 seed in the conference. Detroit has won the last two meetings, including a 26-20 overtime win in September 2024. The Rams enter as 5.5-point home favorites. Sunday’s largest spreads include Raiders vs. Eagles (-11.5), Titans vs. 49ers (-12.5) and Jets vs. Jaguars (-11.5).
Before making any Week 15 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.
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Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine’s Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team’s historical data and then quantitatively evaluating the strength of the opponent’s defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine’s AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season.Â
For Week 15 NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all 15 games. You can only see the AI predictions for the Week 15 NFL schedule here.
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Top Week 15 NFL AI picks
After analyzing every game in Week 15, the AI says the Cowboys (-6), who have won three of their last four games, cover comfortably against the Vikings. Quarterback Dak Prescott has been on a roll. In 13 games, he has completed 69% of his passes for 3,637 yards and 26 touchdowns with 10 interceptions for a rating of 100.2.
Powering the Dallas rushing attack is fifth-year veteran running back Javonte Williams. In 13 games, he has carried 215 times for 1,022 yards (4.8 average) and nine touchdowns. He has five explosive plays of 20 yards or more, including a long of 66 yards. SportsLine AI rates the Cowboys as an A+ spread pick and also predicts a 30-20 win on average. See its other Week 15 football predictions and football picks at SportsLine, and bet the Cowboys here:
How to make Week 15 NFL picks
In addition, the AI PickBot has generated more than two dozen highly-coveted A picks for Week 15. You need to see the AI’s NFL picks before making any Week 15 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 15 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.