Lakers vs. Spurs prediction, odds, spread: 2025 NBA Cup picks from proven model

The 2025 NBA Cup quarterfinals continue on Wednesday as the Los Angeles Lakers (17-6) host the San Antonio Spurs (16-7). The Lakers are the second seed in the West and the Spurs are No. 3. The winner advances to place the winner of Thunder vs. Suns in the semifinals on Saturday. The Spurs will still be without Victor Wembanyama (calf). The Lakers won the first and only other matchup between these teams this season, beating San Antonio 118-116 on Nov. 8.

Tipoff from Crypto.com Arena in Los Angeles is set for 10 p.m. ET. Los Angeles is the 5.5-point favorite in the latest Spurs vs. Lakers odds, while the over/under for total points scored is 228.5. Before making any Lakers vs. Spurs picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 8 of the 2025-26 NBA season on a sizzling 29-14 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns. Also, see the best Underdog Fantasy picks for Lakers vs. Spurs here.

Now, the model has simulated Lakers vs. Spurs 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Spurs vs. Lakers:

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How to make Lakers vs. Spurs picks

One of SportsLine’s top player props in this game is for De’Aaron Fox to go Under 6.5 assists. He’s averaged 6.3 assists this month and has gone under that mark in three of his past five games. With Wembanyama on the shelf, Fox is asked to be more of a scorer, which cuts into his assist numbers. SportsLine’s model is projecting 5.4 assists in this one, rating this prop as a 3.5 out of 5 starts. 

The model also says one side of the spread hits well over 50% of the time. You can head to SportsLine to see the model’s NBA picks. 

So who wins Spurs vs. Lakers, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.