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    Home»Fantasy»Fantasy baseball lineup advice, betting tips for Monday
    Fantasy

    Fantasy baseball lineup advice, betting tips for Monday

    By Amanda CollinsSeptember 15, 20257 Mins Read
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    Fantasy baseball lineup advice, betting tips for Monday
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    Sep 15, 2025, 07:00 AM ET

    Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. MLB betting tips for each day’s slate of games will also be added in the morning. MLB game odds are provided by ESPN BET, and all fantasy advice is geared toward ESPN 10-team leagues with standard scoring.

    Note: All information is accurate as of the time of publication. For updates, including what you might have missed from last night, as well as any breaking news that might impact today’s MLB slate, be sure to check out the latest fantasy baseball news.


    Jump to: Pitching notes | Hitting notes | Betting tips
    Reliever depth chart


    Pitchers to stream on Monday

    • Kyle Bradish is showing no ill effects from Tommy John surgery with the internal brace procedure. In three outings since his 2025 debut, the righty’s ERA is 2.85 with a 0.94 WHIP. Even more impressive are 21 strikeouts and only two walks in 17 innings. Bradish lines up for three more starts this season, the first on Monday with the Baltimore Orioles visiting the Chicago White Sox and the league’s third lowest wOBA facing right-handed pitching.

    • Jameson Taillon missed a couple of turns with a groin injury. The Chicago Cubs limited him to only 79 pitches in his first game off the IL, but he should be able to handle a normal workload on the road against the Pittsburgh Pirates. Taillon generally doesn’t rack up a bunch of strikeouts, but he’s recorded at least six frames in 11 of his 20 outings, and outs are integral to points league scoring. The Pirates are the least potent team in the league facing righties.

    • With Zack Littell, it’s all about the long ball, yielding a league-leading 34 homers in 171 1/3 innings. When he keeps the ball in the yard, Littell is effective as evidenced by 17 quality starts, tied for the 12th most in MLB. The Cincinnati Reds visit the St. Louis Cardinals, so Littell has a chance to thrive in one of the stingiest home run parks in the league, facing one of the least powerful lineups.

    Today’s best matchups for pitchers

    Baltimore Orioles pitchers vs. White Sox hitters
    Offense: B | Park: D | Umpire: N/A | Temperature: C+ | Wind: C | Away
    The average pitcher would post a 4.05 ERA in this matchup.

    St. Louis Cardinals pitchers vs. Reds hitters
    Offense: B | Park: B | Umpire: N/A | Temperature: D- | Wind: C | Home
    The average pitcher would post a 4.11 ERA in this matchup.

    Washington Nationals pitchers vs. Braves hitters
    Offense: D | Park: A | Umpire: N/A | Temperature: C- | Wind: B | Home
    The average pitcher would post a 4.13 ERA in this matchup.

    Today’s worst matchups for pitchers

    Minnesota Twins pitchers vs. Yankees hitters
    Offense: F | Park: D | Umpire: N/A | Temperature: D | Wind: C | Home
    The average pitcher would post a 5.37 ERA in this matchup.

    Philadelphia Phillies pitchers vs. Dodgers hitters
    Offense: D | Park: F | Umpire: N/A | Temperature: C | Wind: C | Away
    The average pitcher would post a 5.21 ERA in this matchup.

    Los Angeles Dodgers pitchers vs. Phillies hitters
    Offense: D | Park: F | Umpire: N/A | Temperature: C | Wind: C | Home
    The average pitcher would post a 5.05 ERA in this matchup.


    Hitters to stream on Monday

    • Sean Burke managed to hurl five innings in just one of his last six outings. His 4.32 ERA in this span is reasonable, but his 1.72 WHIP is more indicative of his recent struggles. The White Sox host the Orioles and while both clubs are just playing out the string, the Orioles offense has several hitters trying to end the year on a high note or impress the brass for next season. Jeremiah Jackson, Ryan Mountcastle, Dylan Beavers, Tyler O’Neill, Colton Cowser, Samuel Basallo and Coby Mayo are all candidates to stream on an abbreviated Monday ledger.

    Today’s best matchups for hitters

    Arizona Diamondbacks batters vs. Giants pitchers
    SP: B | Bullpen: B | Park: B | Framing: F | Temperature: C | Wind: C | Home
    The average hitter would post a .334 wOBA in this matchup.

    New York Yankees LHB vs. Twins pitchers
    SP: C | Bullpen: A | Park: B | Framing: B | Temperature: B | Wind: C | Away
    The average hitter would post a .328 wOBA in this matchup.

    Chicago Cubs LHB vs. Pirates pitchers
    SP: C | Bullpen: B | Park: C | Framing: C | Temperature: B | Wind: C | Away
    The average hitter would post a .326 wOBA in this matchup.

    Today’s worst matchups for hitters

    Washington Nationals RHB vs. Braves pitchers
    SP: D | Bullpen: A | Park: F | Framing: C | Temperature: C | Wind: D | Home
    The average hitter would post a .289 wOBA in this matchup.

    Los Angeles Dodgers LHB vs. Phillies pitchers
    SP: F | Bullpen: F | Park: A | Framing: B | Temperature: C | Wind: C | Home
    The average hitter would post a .298 wOBA in this matchup.

    Philadelphia Phillies LHB vs. Dodgers pitchers
    SP: C | Bullpen: F | Park: A | Framing: C | Temperature: C | Wind: C | Away
    The average hitter would post a .299 wOBA in this matchup.


    Betting tips

    Best/worst pitcher/hitter matchups and betting projections are generated by THE BAT X, a system created by Derek Carty using advanced methods like those used in MLB front offices, accounting for a variety of factors including player talent, ballparks, bullpens, weather, umpires, defense, catcher pitch-framing, and lots more. Betting projections for every player, team, and game can be found at EV Analytics.

    Note: Expected Value is a measure of how good a bet is, factoring the probability that it will win versus the odds the book is providing. If you were to wager $1.00 100 times on a bet with an Expected Value of $25, you would win some and you would lose some, but in the end you would expect to come away with $25 in profit on your $100 investment.

    Today’s top HR prop bets

    Yandy Diaz | OVER 0.5 HR (+550)
    Projection: 17% chance of this bet hitting, with a $9.20 EV
    One reason to bet this: Last season, Diaz had an average launch angle of 1.3 degrees on his hardest-hit balls, while this season it has significantly increased to 5.4 degrees.

    Tyler O’Neill | OVER 0.5 HR (+400)
    Projection: 22% chance of this bet hitting, with a $8.70 EV
    One reason to bet this: O’Neill’s flyball exit velocity (a reliable standard to evaluate power) is in the 90th percentile at 96.5 mph.

    Wilmer Flores | OVER 0.5 HR (+900)
    Projection: 11% chance of this bet hitting, with a $5.80 EV
    One reason to bet this: Flores has seen a big increase in his exit velocity this season. Compare his 85.5-mph average to last year’s 83.5-mph EV.

    Today’s top pitcher prop bets

    Kyle Bradish | UNDER 5.5 K (-130)
    Projection: 65% chance of this bet hitting, with a $19.87 EV
    One reason to bet this: The Chicago White Sox have six hitters in their projected offense who will receive the benefit of the platoon advantage against Bradish in today’s game.

    Zack Littell | UNDER 3.5 K (+105)
    Projection: 52% chance of this bet hitting, with a $7.56 EV
    One reason to bet this: The No. 2 park in the majors for suppressing strikeouts, according to my projections, is Busch Stadium.

    Spencer Strider | OVER 6.5 K (+110)
    Projection: 51% chance of this bet hitting, with a $6.43 EV
    One reason to bet this: Recording an average of 93.8 adjusted pitches per outing this year, Strider lands in the 86th percentile.

    Today’s top YRFI/NRFI bets

    Blue Jays @ Rays | NRFI (-105)
    Projection: 54% chance of NO RUN with a $5.31 EV

    Rangers @ Astros | YRFI (-105)
    Projection: 52% chance of RUN with a $2.50 EV

    Yankees @ Twins | YRFI (-115)
    Projection: 54% chance of RUN with a $1.59 EV

    advice baseball betting Fantasy Lineup Monday tips
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