Photo By – Imagn Images. Kansas City Chiefs quarterback Patrick Mahomes (15) passes the ball against the Philadelphia Eagles.
Week 3 of the NFL season brings the first real tests of staying power. Fast starts meet stiffer competition, struggling teams fight to reset, and every matchup begins to shape this season’s direction. It’s the weekend when early storylines start turning into lasting realities.
Instead of leaving the picks to the talking heads, we’ve turned to artificial intelligence. Using the Week 3 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.
Here’s how the AI sees Week 3 shaking out with its NFL picks.
ChatGPT has gone 28-4 so far this season for +23.6 units.
Week 3 NFL moneyline picks
Lines courtesy of FanDuel.
Dolphins vs Bills: 
Bills (-850)
Buffalo is 2-0 and much more in rhythm than the Dolphins, who have looked shaky in both offense and defense. Josh Allen & Co. should dominate, especially at home. Miami has shown flashes, but consistency and defensive weaknesses will cost them here.
Colts vs Titans: 
Colts (-205)
Indianapolis has shown more balance, especially through the air with Daniel Jones, and should be able to control tempo. Tennessee has been behind early and has defensive vulnerabilities. On the road, the Colts are likely to find just enough to win straight-up.
Steelers vs Patriots: 
Steelers (-130)
Even though New England has had moments, Pittsburgh may be more battle-tested in close games and better positioned to take advantage of miscues. The line is close, so this is slightly riskier, but the Steelers look more likely to pull this one out.
Jets vs Buccaneers: 
Buccaneers (-320)
The Jets are dealing with quarterback disruption, while the Bucs have managed to pull through tight spots in earlier games. Tampa Bay, at home, should be able to exploit New York’s weakened offense. Though the payout isn’t huge, the Buccaneers look safer in this spot.
Raiders vs Commanders: 
Commanders (-186)
There are some question marks for Washington (e.g. quarterback health), but they have enough home strength and a favorable matchup to edge this. Las Vegas hasn’t shown consistency so far. If the Commanders can avoid turnovers, they should pull this one out.
Rams vs Eagles: 
Eagles (-190)
The Eagles are 2-0, coming off a win in the Super Bowl rematch. They’ve been efficient and resilient. The Rams have had flashes but concerns about offensive line and consistency could derail them in Philadelphia. The Eagles, especially at home, are the safer pick.
Falcons vs Panthers: 
Falcons (-250)
Atlanta had a strong showing in Week 2, especially defensively, and are favored for a reason. Carolina is still trying to find consistency, particularly on offense. The line suggests confidence in the Falcons, and I agree: Atlanta should win outright.
Bengals vs Vikings: 
Vikings (-144)
With Joe Burrow out, the Bengals are a different team. Minnesota has its own issues but as favorites at home and with fewer questions, they have a better chance to deliver. Lean Vikings.
Texans vs Jaguars: 
Texans (+120)
Houston looks like it has an easier profile this week. The Jaguars have had moments but have shown vulnerability, especially in defense. If the Texans can limit turnovers and get consistent offense, they should take this.
Packers vs Browns: 
Packers (-430)
Green Bay has started the season well, while the Browns are 0-2 with serious offensive struggles. The gap in team strength, especially at QB and supporting roles, favors the Packers heavily. Green Bays is on the road, but still much more likely to win.
Broncos vs Chargers: 
Chargers (-154)
The Chargers are at home, where they are a slight favorite, and they appear more consistent to this point. The Broncos have shown flashes but not enough to trust them outright.
Saints vs Seahawks: 
Seahawks (-390)
Seattle has more stability and should dominate this matchup. The Saints are still trying to find a reliable offensive identity, especially on the road. Seattle is a big favorite for a reason.
Cardinals vs 49ers: 
49ers (-120)
The 49ers have been impressive even without some key names, and their defense remains elite. The Cardinals have put up competitive numbers, but the Niners’ home advantage and cohesion give them the edge.
Cowboys vs Bears: 
Cowboys (-108)
This is one of the tighter matchups. The Bears are favored at home, but their defense gave up a lot in earlier games and offense hasn’t been totally steady. The Cowboys have explosive potential and may outscore. I’ll back Dallas in this close one.
Chiefs vs Giants: 
Chiefs (-270)
Both teams started 0-2, but Kansas City has shown more individual weaponry and offensive upside. The Giants have put up yards but their defense and discipline are questionable. On the road in primetime, the Chiefs make key adjustments and get this one.
Lions vs Ravens: 
Ravens (-250)
Baltimore at home is tough, especially under the lights. Detroit lit up their matchup in Week 2, but consistency is still a question. The Ravens have shown more balance; this is a spot where home factors and coaching matter. Ravens to take it.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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