A rematch years in the making lands at the Sphere in Las Vegas and streams globally on Netflix. Here’s an early look at Mayweather vs. Pacquiao 2 odds.
Photo By – Reuters Connect. Manny Pacquiao gainst Floyd Mayweather during their boxing bout.
The first fight broke records. The rematch will break the internet.
Floyd Mayweather and Manny Pacquiao meet again on September 19 at the Sphere in Las Vegas, streaming globally on Netflix.
FLOYD MAYWEATHER vs. MANNY PACQUIAO
Two of the greatest icons in boxing history will meet again in the first-ever professional boxing match at Sphere in Las Vegas.
Saturday September 19
LIVE globally only on Netflix#MayPac2 pic.twitter.com/3i5FtXBzgX— Netflix (@netflix) February 23, 2026
Sportsbooks have released opening odds for the September 19 rematch, installing Mayweather as a -225 favorite over Pacquiao.
Mayweather vs Pacquiao odds
| Fighter | Odds |
|---|---|
| Floyd Mayweather Jr. | -225 |
| Manny Pacquiao | +171 |
Odds as of February 23.
Mayweather opened as a -225 favorite, slightly shorter than his -240 closing price in their first meeting. That suggests books are accounting for age and inactivity, while still respecting his defensive style and previous head-to-head edge.
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Breaking down the opening line
With the rematch confirmed as a sanctioned professional bout under standard rules, sportsbooks had a clear framework for pricing risk. Twelve three-minute rounds, official judges, approved gloves, and commission oversight reduce uncertainty and allow bookmakers to lean on traditional boxing models when setting a line.
That structure helps explain why Mayweather opened as a -225 favorite. Oddsmakers can reference the first fight’s tactical pace and decision outcome rather than guessing how exhibition-style rules might affect volatility.
The first fight blueprint
The pair’s first fight on May 2, 2015, went 12 rounds, and Mayweather won a clear unanimous decision as a -240 favorite.
That fight drew a record 4.4 million pay-per-view buys and more than $600 million in revenue. Events of that scale attract massive betting handle, meaning sportsbooks should expect significant early action when lines open.
It wasn’t dramatic. It was controlled. Mayweather set the pace, defended well, and landed cleaner shots. Pacquiao had a few strong moments, but he couldn’t consistently break through.
The important part for bettors: it went the distance, and it was tactical, not violent.
With both fighters now approaching 50, the opening line of Mayweather -225 suggests sportsbooks expect a similar tactical script, favoring control and experience over volatility.
Pacquiao opening at +171 creates a natural underdog draw, and early public action could test whether that number holds.
Current form and activity
Floyd Mayweather officially retired in 2017 after beating Conor McGregor, but he’s stayed active through exhibitions and high-profile events. At 48, he’s still involved in the spotlight and is scheduled for another exhibition bout in April against Mike Tyson.
Manny Pacquiao retired in 2021 before returning to the ring last July, fighting Mario Barrios to a majority draw in a WBC welterweight title bout. He showed flashes of his old speed, but at 47, the pace isn’t what it once was. Pacquiao is also set for an April exhibition against Ruslan Provodnikov.
For bettors, the key question is timing. Both fighters are staying active, but neither has been in consistent, elite-level competition in recent years. That uncertainty is now reflected in a line that makes Mayweather a clear favorite, but not an overwhelming one.
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Mayweather vs Pacquiao FAQs
The rematch is scheduled for September 19 at the Sphere in Las Vegas and will stream globally on Netflix.
Yes. Floyd Mayweather has been tabbed as a -225 favorite with Manny Pacquiao the underdog at +171.
Mayweather opens as a -225 favorite. Pacquiao checks in at +171.
Once odds are available, major online sportsbooks are expected to offer moneylines, totals, and method-of-victory props.
Mayweather defeated Pacquiao by unanimous decision after 12 rounds, controlling pace and landing more efficiently throughout the bout.