Wednesday’s MLB DFS main slates differ between DFS providers. DraftKings’ slate features eight games, starting at 7:05 p.m. ET. FanDuel’s slate has 12 games, beginning at 6:40 p.m. ET. The Underdog pick’em selections are from the 12-game slate. Let’s dive into our top MLB DFS picks.
Wednesday’s Top MLB DFS Picks & Player Props
Wednesday’s Starting Pitcher Rankings (4/15)
Wednesday’s MLB DFS main slates differ between DFS providers. DraftKings’ slate features eight games, starting at 7:05 p.m. ET. FanDuel’s slate has 12 games, beginning at 6:40 p.m. ET. The Underdog pick’em selections are from the 12-game slate. Let’s dive into our top MLB DFS picks.
Wednesday’s Top MLB DFS Picks & Player Props
Wednesday’s Starting Pitcher Rankings (4/15)
Shohei Ohtani (SP – LAD) vs. New York Mets
Shohei Ohtani threw 87 pitches against the Guardians in his first start this year and 96 against the Blue Jays in his second turn. The Dodgers haven’t heavily restricted his pitch count to this point.
Through 12 innings in those two starts, Ohtani allowed only one unearned run on five hits, four walks and one hit batter. The two-way stud’s 17% strikeout rate, 9.3 SwStr% and 25.7 CSW%, per FanGraphs, have left something to be desired. Nevertheless, Ohtani’s pitch-modeling includes 108 stuff+, 93 location+ and 100 pitching+. The strikeouts should come.
The betting info cements Ohtani’s status as tonight’s top pitching option. The Dodgers are -225 favorites, and the game’s total is eight runs.
Dylan Cease (SP – TOR) at Milwaukee Brewers
Dylan Cease is tailor-made for GPPs. The 30-year-old righty’s 13.4% wak rate through three starts is a recipe for a stinker if he can’t work around his free passes. At the same time, his 38.8% strikeout rate is 8.2% higher than the second-highest rate among tonight’s probable starters. Strikeouts equal fantasy points, and Cease’s ceiling is unmatched on tonight’s slate.
Cease also has favorable betting info. The Blue Jays are slight favorites (-120), and the game’s total is a pitcher-friendly 7.5 runs.
Spencer Arrighetti (SP – HOU) vs. Colorado Rockies
Spencer Arrighetti opened this year by toying with Triple-A hitters. In three starts spanning 14.1 innings in Triple-A this season, Arrighetti has logged the following stats:
- 1.26 ERA
- 3.50 xFIP
- 0.77 WHIP
- 10.9% walk rate
- 36.4% strikeout rate
- 11.8 SwStr%
- 29.7 CSW%
The projected starters for the Rockies shouldn’t be a sizable step up from what Arrighetti has seen in Triple-A. The 26-year-old righty and the Astros are also -170 favorites, making him a compelling SP2 option across game types at DraftKings tonight.
Suggested Lineup Stacks
Atlanta’s projected starting lineup features six hitters with at least a 105 wRC+ against righties since 2024, and three have had at least a 129 wRC+. Atlanta’s lineup has a nifty blend of depth and high-end talent.
The Braves also have a desirable matchup against Chris Paddack. The veteran righty has a 6.14 ERA, 4.32 xERA, 3.98 xFIP and 3.89 SIERA in three appearances (two starts) this year. While his ERA estimators suggest he’ll pitch better, Paddack’s struggles against lefties and righties are eye-catching. He’s coughed up a .336 wOBA to lefties and a .343 wOBA to righties since last season.
Randy Vasquez‘s numbers through three starts are blistering, and gamers might get over their skis rostering him on a pitching-poor slate. As a result, leveraging that in GPPs by stacking the Mariners against him is appealing.
Eight of the team’s projected starters have posted at least a 101 wRC+ against righties since 2024, and seven have had at least a 116 wRC+. They have depth and have collectively hammered righties. Moreover, the depth and the salaries for Seattle’s hitters open the door to a double-aces DFS roster, doubling up on Shohei Ohtani and Dylan Cease at DraftKings.
Core Studs
- Corey Seager has hit 41 homers with a .389 on-base percentage (OBP), .250 ISO, .389 wOBA and 156 wRC+ in 730 plate appearances against righties since 2024.
- Matt Olson has ripped 45 round-trippers with a .360 OBP, .214 ISO, .359 wOBA and 131 wRC+ in 1,055 plate appearances against righties since 2024.
- Cam Smith is breaking out in his sophomore campaign. He has hit three homers with 12 runs, nine RBI, three stolen bases, a .361 OBP, .203 ISO, .378 wOBA and 143 wRC+ through 72 plate appearances this year.
Value Plays/Punts
- Mike Yastrzemski has hit 33 dongs with a .332 OBP, .203 ISO, .336 wOBA and 117 wRC+ in 882 plate appearances against righties since 2024.
- Austin Riley has hit 26 homers with a .311 OBP, .177 ISO, .322 wOBA and 105 wRC+ in 745 plate appearances against righties since 2024.
- Cole Young is a less appealing selection on FanDuel than on DraftKings, and Jeff McNeil is a rock-solid pivot at FanDuel. Second base is an excellent position to punt tonight, and Young has been an above-average hitter in his sophomore campaign.
Wednesday’s Top 3 Underdog Player Props
Check out our best picks on the MLB Underdog Cheat Sheet 
Matt Olson (1B – ATL): 1. 5 Hits + Runs + RBIs — Higher (0.83x Payout)
Matt Olson has rattled off 21 hits, 14 runs, 12 RBI, a .296 batting average, .375 OBP, .296 ISO, .418 wOBA and 164 wRC+ in 80 plate appearances this season.
The left-handed slugger has surpassed 1.5 combined hits + runs + RBIs in three straight games and six of his past seven.
Mike Yastrzemski (OF – ATL): 1.5 Hits + Runs + RBIs — Higher
Mike Yastrzemski’s pick’em positively correlates with Olson’s. The veteran outfielder has cleared this threshold in three straight games.
Jonathan Aranda (1B – TB): 1.5 Total Bases — Higher (1.03x Payout)
Jonathan Aranda‘s exit velocity surge and uptick in launch angle from 2025 have carried over to 2026.
As a result, he has 14 hits (eight singles, three doubles and three homers), a .222 batting average, .413 slugging rate and .190 ISO in 75 plate appearances, and his expected stats indicate he’s been unlucky.
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Josh Shepardson is a featured writer at FantasyPros. For more from Josh, check out his archive and follow him @BChad50.