It’s Tuesday, July 22 and the Orioles (44-55) are in Cleveland to take on the Guardians (49-50). Brandon Young is slated to take the mound for Baltimore against Joey Cantillo for Cleveland.
The Guardians took the first game of the series, 10-5, behind a four-run sixth inning. Cleveland is 3-1 since the break and has scored 28 runs. Baltimore is 1-3 post-break and totaled 14 runs in that span with 10 coming in the past two games.
Let’s dive into the matchup and find a sweat or two. We’ve got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Orioles at Guardians
- Date: Tuesday, July 22, 2025
- Time: 6:40PM EST
- Site: Progressive Field
- City: Cleveland, OH
- Network/Streaming: MASN2, CLEG
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Odds for the Orioles at the Guardians
The latest odds as of Tuesday:
- Moneyline: Orioles (+118), Guardians (-140)
- Spread: Guardians -1.5
- Total: 8.0 runs
Probable starting pitchers for Orioles at Guardians
- Pitching matchup for July 22, 2025: Brandon Young vs. Joey Cantillo
- Orioles: Brandon Young, (0-4, 7.52 ERA)
Last outing: 4.1 Innings Pitched, 7 Earned Runs Allowed, 9 Hits Allowed, 0 Walks, and 4 Strikeouts - Guardians: Joey Cantillo, (1-0, 4.17 ERA)
Last outing: 5.1 Innings Pitched, 4 Earned Runs Allowed, 7 Hits Allowed, 0 Walks, and 6 Strikeouts
- Orioles: Brandon Young, (0-4, 7.52 ERA)
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Expert picks & predictions for tonight’s game between the Orioles and the Guardians
Rotoworld Best Bet
Vaughn Dalzell (@VmoneySports) likes the Guardians to reach 80 wins:
“In the first 24 games of the 67 one second-half of the schedule are the Athletics, Orioles, Royals, Rockies, Twins, Mets, White Sox, and Marlins — beautiful! Cleveland took the series against the A’s, 2-1 and beat the O’s in the opener— so far so good.
The Guardians have the easiest strength of schedule remaining in the MLB and need a 34-33 record over the second half to secure 80-plus wins, which I believe is more than possible.”
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Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday’s game between the Orioles and the Guardians:
- Moneyline: NBC Sports Bet is recommending a play on the Cleveland Guardians on the Moneyline.
- Spread: NBC Sports Bet is leaning towards a play ATS on the Baltimore Orioles at +1.5.
- Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Orioles at Guardians
- The Guardians have won 7 of their last 8 matchups against American League teams
- 6 of the Orioles’ last 8 road trips to the Guardians have gone over the Total
- Cleveland is 3-1 in the last four games and 3-1 ATS
- Baltimore is 1-3 on the ML and 2-2 ATS in the past four
If you’re looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Follow our experts on socials to keep up with all the latest content from the staff:
- Jay Croucher (@croucherJD)
- Drew Dinsick (@whale_capper)
- Vaughn Dalzell (@VmoneySports)
- Trysta Krick (@Trysta_Krick)