League One Port Vale’s reward for beating Sunderland in the FA Cup is a quarter-final tie away to Chelsea, while Manchester City will host Liverpool in a heavyweight showdown.
Record 14-time winners Arsenal go to Southampton, eighth in the Championship.
Leeds United will travel to the winners of Monday’s tie between West Ham United and Brentford.
Port Vale are the lowest ranked side left in the competition. It will be the first time they have met Chelsea in a competitive fixture since 1929.
The ties will be played across the weekend of 4-5 April.