Week 10 of the 2025 fantasy football season featured huge days by a mix of every position, but also several disappointing efforts by some of the league’s best options.
Who were the big winners and losers?
Matt Bowen and Tristan H. Cockcroft offer their analyses.
Jump to a topic:
Ranking winners | Ranking losers
Biggest injuries and what’s next
Ranking fantasy winners of Week 10
1. Jonathan Taylor, RB, Indianapolis Colts: In his highlight game — thus far — of a massive season, Taylor scored 49.6 fantasy points, the most by any player this season and tied for 36th on the all-time single-game list among running backs. Yes, it came in an overtime game, and yes, he had a massive amount of volume (32 carries and 35 total touches), but Taylor’s 83-yard rushing score in the fourth quarter rallied his team from behind, and he polished off the victory in overtime by rushing the final 33 yards in the Colts’ winning drive. Those two touchdowns, along with his 1-yard first-quarter rushing score, gave him his fifth game this season with at least three, tying him with Chuck Foreman (1975) and Marshall Faulk (2000) for the second-most such games in a single season behind only LaDainian Tomlinson’s six (2006). With the performance, which was remarkably not Taylor’s career best (53.4 FPTS, Week 11 of 2021), Taylor has recaptured the overall scoring lead with 273.9. His fantasy managers can have but two quibbles: his disappointing Week 9 (7.7 FPTS), and that they’ll struggle to replace his production during his Week 11 bye. — Cockcroft
2. De’Von Achane, RB, Miami Dolphins: His 40.5 fantasy points were not a career high only because his best single-game total (51.3 in Week 3 of 2023) came in his breakout, rookie-season game. Achane’s success came largely via the run, for once, as his Dolphins unexpectedly dominated the Buffalo Bills, winning 30-13. His 29.4 points on 22 rushing plays was just shy of his 32.3 in that aforementioned rookie-year contest. His five carries for double-digit yardage were a career high, and he had 72 more rushing yards than expected. Even with his Dolphins in the midst of a terrible year, Achane is getting the two-way volume to be a weekly top-five running back. — Cockcroft
3. Jahmyr Gibbs, RB, Detroit Lions: For the second time in the past four weeks, he scored in excess of 35 fantasy points, his 38.2 in Week 10 the second-best single game effort of his three-year NFL career (46.0, Week 18 of 2024). Gibbs matched his personal best with four carries of double-digit yardage and totaled 49 more rushing yards than expected, per NFL Next Gen Stats, while also adding 12 points receiving. Though he has shown some inconsistency in recent weeks, he’s an unquestioned weekly top-five play at the position. — Cockcroft
4. TreVeyon Henderson, RB, New England Patriots: In his second consecutive start filling in for the injured Rhamondre Stevenson (toe), Henderson finally broke out, scoring a personal-best 28.0 fantasy points against the Tampa Bay Buccaneers. It was his 69-yard rushing touchdown with one minute, 31 seconds remaining that put the final touch on a 28-23 victory, his second rushing score of 50-plus yards for the day. He’s the only player who can claim as many in a single game this season. That should guarantee Henderson more of a home-run-hitting role in the coming weeks, and if he starts again for Stevenson in Week 11 against the New York Jets, he’ll be a midrange RB2 with upside. — Cockcroft
5. Trey McBride, TE, Arizona Cardinals: The switch at quarterback to Jacoby Brissett has paid huge dividends for McBride and his fantasy managers, as for the third time in the Cardinals’ past four games — matching Brissett’s tenure as the Cardinals’ starter — the tight end scored at least 21 fantasy points (27.7). McBride has scored 94.8 points during that span, easily the position’s most over those five weeks, which is remarkable considering his bye was included. He’ll give Brock Bowers genuine competition for the status of No. 1 tight end moving forward. — Cockcroft
6. Jaxson Dart, QB, New York Giants: He’s a winner with a caveat. For the third time in the past four weeks, Dart scored 26-plus fantasy points, totaling 26.28 points through three quarters of play. That gave him a total of 160.38 points through his first seven career starts, eighth most among quarterbacks in history. That said, “through three quarters” is a critical note because Dart took a nasty hit on a rushing play that resulted in a third-quarter lost fumble, leaving the game for concussion evaluation. It’s yet another setback for the snakebit Giants, and we’ll see whether the injury lingers into Week 11. If it does, Russell Wilson, who scored 3.0 fantasy points in fourth-quarter relief, will fill in and take some of the excitement out of the offense. A healthy Dart, meanwhile, has arrived as a weekly starter. — Cockcroft
7. Caleb Williams, QB, Chicago Bears: Williams made plays late for this Bears team in the comeback win over the Giants — scoring 25.1 points — and we saw his dual-threat ability on second-reaction scramble attempts. Yes, Williams threw for 220 yards and a score in this one, but it was the rushing numbers that boosted his Week 10 totals. Williams rushed for 68 yards on eight carries, which included the game-winning touchdown off a boot concept. Open grass for Williams there. Williams has scored 25 or more points in back-to-back games, with at least 50 yards rushing in each. His willingness to extend plays as a runner is part of his game. Keep Williams in the QB1 mix for the Week 11 matchup versus the Minnesota Vikings. –Bowen
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Eric Moody: Drake London firmly on the WR1 radar moving forward
Eric Moody breaks down his fantasy optimism for Drake London heading into a matchup vs. the Panthers.
8. Drake London, WR, Atlanta Falcons: London dropped 24.4 points on the Colts in Week 10, catching six of eight targets for 104 yards, and he found the end zone (again). London has caught at least one touchdown while scoring 24 or more points in four of his past five games. With ball skills, scheme, body control and more, he is making plays. And with the Carolina Panthers up next, London should be locked in as a WR1. –Bowen
9. Jameson Williams, WR, Detroit Lions: He scored a season-best 23.9 fantasy points despite his Lions easily defeating the Washington Commanders 44-22. Williams managed to catch six of his seven targets with a 10.6-yard average depth of target, underscoring his big-play potential. He has touchdowns in three of his past four games. Williams faces a tougher matchup against the Philadelphia Eagles in Week 11, but he’ll be a risk/reward WR3 or flex for that game. — Cockcroft
10. Emeka Egbuka, WR; Tez Johnson, WR, Tampa Bay Buccaneers: Egbuka, who had fewer than 10 points in each of his previous three games while working through a hamstring injury, scored 23.5 points in the Week 10 matchup versus New England. The play speed jumped, and Egbuka showed no signs of the injury, catching six of a team-high 13 targets for 115 yards and a touchdown. With Chris Godwin Jr. (fibula) still sidelined, Johnson had 42 yards receiving on four receptions, two of them going for touchdowns. That was good for a career-high 20.2 points. Johnson was started in only 6.1% of ESPN leagues, and he’ll remain a viable WR3 if Godwin is out for the Week 11 game at Buffalo, while Egbuka belongs in the WR1 ranks. –Bowen
11. George Kittle, TE, San Francisco 49ers: Kittle’s 23.4 points in Sunday’s loss to the Rams were a season high and the second most for a tight end in Week 10 through the late window games. Kittle caught all nine of his targets from quarterback Mac Jones, totaling 84 yards and a touchdown. With a positive Week 11 matchup versus the Cardinals’ defense up next, Kittle will remain a top-five play at the position. — Bowen
Ranking fantasy losers of Week 10
1. Justin Jefferson, WR, Minnesota Vikings: The most-started wide receiver (97.8% of ESPN leagues), Jefferson wound up one of the biggest disappointments in Week 10, scoring only 7.7 fantasy points despite 12 targets. Baltimore Ravens cornerbacks Marlon Humphrey and Nate Wiggins bottled him up all day, and J.J. McCarthy threw both of his interceptions on throws in Jefferson’s direction. Credit the improving Ravens defense for this result, but Jefferson should rebound with huge numbers in a great Week 11 matchup against the Chicago Bears. — Cockcroft
2. Bijan Robinson, RB, Atlanta Falcons: He scored only 10.8 fantasy points in the Falcons’ 31-25 overtime loss to the Indianapolis Colts in Berlin, giving him only 34.2 points in the past three weeks combined. Robinson strangely ran only 17 times despite the extra time, and he was less involved in the receiving game than usual (two targets, both caught, for 4 yards total). He should rebound in Week 11 against the Carolina Panthers. — Cockcroft
3. James Cook III, RB, Buffalo Bills: Negative game flow disrupted the rushing volume for Cook on Sunday in the blowout loss at Miami. Cook’s 13 carries tied a season low as he rushed for 53 yards. Cook did have five receptions, which pushed his scoring total in double figures (10.7 points), but this Buffalo offense failed to establish a sense of tempo and rhythm in this one. Cook will look to bounce back in a positive Week 11 matchup versus the Tampa Bay Buccaneers. –Bowen
4. Michael Pittman Jr., WR, Indianapolis Colts: Pittman wasn’t heavily involved in the Week 10 game plan versus Atlanta, catching both of his targets for only 19 yards, which produced a season-low 3.9 points. With Tyler Warren (10 targets) and Alec Pierce (7 targets) seeing more looks, Pittman simply didn’t get enough work. Pittman had scored 20 or more points in each of his past three games, and he’ll be back in WR2 ranks when the Colts return from the bye in Week 12 at Kansas City. — Bowen
5. Sam Darnold, QB, Seattle Seahawks: On a mistake-filled day for Darnold, one that featured extremely low throwing volume, the quarterback had a season-low 4.92 points. Darnold accounted for three turnovers in this game (2 fumbles, 1 interception), and he attempted only 12 passes, completing 10 for 178 yards and a touchdown. That’s a big drop from last week’s 27.2 points in the win over the Washington Commanders. Darnold will look to rebound in Week 11 on the road against the Los Angeles Rams. — Bowen
6. Bo Nix, QB; Courtland Sutton, WR, Denver Broncos: That Broncos’ pass game was a tough watch in the Thursday night win over the Raiders. Nix finished with a season-low 5.8 points, throwing for 150 yards with one touchdown and two picks, plus he failed to produce as a runner (5 carries, minus-2 yards). Nix’s footwork looked frenetic, and the deep ball interception highlighted his lack of a power arm. Sutton, who continues to lose target volume to Troy Franklin, caught three of four for 24 yards (5.4 points). Nix will remain a lower-tier QB1 in my ranks for the Week 11 home game versus Kansas City, while Sutton fits as a flex option. –Bowen
7. Brock Bowers, TE, Las Vegas Raiders: From a 43.3-point Week 9, then the best individual score by any player this season (see Taylor above for the new owner of said honor), to a 3.7 point Thursday night performance, Bowers certainly has frustrated his managers this season. Forgive him somewhat for this one, as the Denver Broncos’ stingy pass defense was largely behind it, but it’s fair to point to Geno Smith’s struggles passing as a contributing factor in Bowers’ inconsistency. Fortunately for his fantasy managers, he draws a fantastic Week 11 matchup in the Dallas Cowboys, so expect a rebound to bigger point totals. — Cockcroft
Injury impact
Dalton Kincaid, TE, Buffalo Bills
What we know: He left Sunday’s game early in the third quarter to a hamstring injury and was unable to return.
What’s next: Dawson Knox, who played 68% of the offensive snaps for the day and scored 6.7 fantasy points, will take over the pass-catching tight end duties for the Bills if Kincaid is unable to play in Week 11. — Cockcroft
Davante Adams, WR, Los Angeles Rams
What we know: He left in the fourth quarter with a back injury and was unable to return. Fortunately for his managers, he scored 19.7 fantasy points before departing.
What’s next: Adams’ recent history of minor injuries makes him someone to track throughout the practice week. Puka Nacua will continue to see a huge number of targets if Adams needs to miss Week 11, while tight end Colby Parkinson could see an increase in work. — Cockcroft