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    Home»Fantasy»Fantasy baseball lineup advice and betting tips for Wednesday
    Fantasy

    Fantasy baseball lineup advice and betting tips for Wednesday

    Amanda CollinsBy Amanda CollinsJuly 22, 2025No Comments4 Mins Read0 Views
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    Fantasy baseball lineup advice and betting tips for Wednesday
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    • Todd ZolaJul 22, 2025, 05:00 PM ET

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        Todd Zola is contributing writer for fantasy baseball at ESPN, specializing in game theory and player analysis. Todd is a member of the FSWA Hall of Fame. He won LABR and Tout Wars championships in 2016.

    Check out all of our starting pitcher rankings and other lineup selection tools here to help you make smart fantasy baseball lineup decisions. MLB betting tips for each day’s slate of games will also be added in the morning. MLB game odds are provided by ESPN BET, and all fantasy advice is geared toward ESPN 10-team leagues with standard scoring.

    Note: All information is accurate as of the time of publication. For updates, including what you might have missed from last night, as well as any breaking news that might impact today’s MLB slate, be sure to check out the latest fantasy baseball news.


    Jump to: Pitching notes | Hitting notes | Betting tips
    Reliever depth chart | Start a new league


    Pitchers to stream on Wednesday

    • The Tampa Bay Rays hope that Taj Bradley‘s last two efforts heading into the break are a harbinger of how he’ll produce down the stretch. The righty posted a pair of quality starts, fanning 11 in 12 frames with just four walks. He hasn’t allowed a homer in 29 2/3 innings. Bradley is in a favorable position to keep the momentum with a home start against a Chicago White Sox lineup with the lowest wOBA against right-handers.

    • Sean Manaea may not be fully stretched out, but after tossing 65 and 69 pitches in his two outings heading into the break, he should be able to handle five frames and qualify for a possible win when the New York Mets host the Los Angeles Angels. The visitors strike out at the league’s highest clip against left-handers.

    • Early in the season, the Milwaukee Brewers needed starting pitching, so they acquired Quinn Priester from the Boston Red Sox. The 25-year-old righty was unable to deliver on his prospect hype, but like they’ve done several times lately, the club saw something they liked and have been rewarded. Over his last four outings, Priester posted a 2.28 ERA and 0.89 WHIP, with an ace-like 30 punchouts to only six free passes in those 23 2/3 innings. Wednesday’s road date with the Seattle Mariners will be a challenge, but after fanning 10 Los Angeles Dodgers in six scoreless frames last time, Priester has earned the fantasy start.


    Hitters to stream on Wednesday

    Hitters to avoid on Wednesday

    • Normally, it’s a no-brainer to trust Red Sox batters against southpaw pitching, after all they sport the third highest wOBA in MLB facing left-handers. However, the righty swingers like Rob Refsnyder and Romy Gonzalez have played sparingly lately and could be overmatched facing Jesus Luzardo. The Philadelphia Phillies’ left-hander has been inconsistent, but he logged four double-digit strikeout efforts plus six more outings where he notched at least seven punchouts and the Red Sox are vulnerable to strikeout pitchers.


    Betting tips

    Best/worst pitcher/hitter matchups and betting projections are generated by THE BAT X, a system created by Derek Carty using advanced methods like those used in MLB front offices, accounting for a variety of factors including player talent, ballparks, bullpens, weather, umpires, defense, catcher pitch-framing, and lots more. Betting projections for every player, team, and game can be found at EV Analytics.

    Note: Expected Value is a measure of how good a bet is, factoring the probability that it will win versus the odds the book is providing. If you were to wager $1.00 100 times on a bet with an Expected Value of $25, you would win some and you would lose some, but in the end you would expect to come away with $25 in profit on your $100 investment.

    Because odds typically do not get set until the previous day’s games are completed, betting tips will be added in the morning.

    advice baseball betting Fantasy Lineup tips Wednesday
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