Trevor Knapp
• Betting Analyst
7+ years betting experience
Updated:
Oct 11, 2026 , 09:30 PM ET
• 4 min read
Trevor Knapp breaks down his best NFL moneyline picks for Week 5, including the Los Angeles Rams on Monday Night Football.
Photo By – Reuters Connect. Los Angeles Rams running back Kyren Williams (23) celebrates after scoring a touchdown against the Philadelphia Eagles
Coming off a 12-4 week for +4.98 units, I’m looking to keep the momentum rolling with my NFL moneyline picks for Week 6.
Sunday was spotty, but we can still finish strong by backing two prime-time favorites: the Atlanta Falcons and the Los Angeles Rams.
Let’s keep stacking winners in my latest NFL picks.
My NFL moneyline record is 42-22 this season for +7.48 units.
NFL moneyline picks for Week 5
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Expert Week 5 NFL moneyline picks
Ravens vs. Falcons: 
Falcons
The chances of Lamar Jackson starting Sunday night in Atlanta are slim at best, and even if he does, it’s hard to look past a Falcons team that has found its rhythm with Michael Penix Jr. under center and boasts the league’s highest pressure rate on D.
Best of luck to Tyler “Snoop” Huntley.
Check out our full Ravens vs. Falcons predictions!
Bills vs. Rams: 
Rams
With Ed Oliver and D.J. Moore’s statuses up in the air, a Rams team fresh off escaping the jaws of defeat in Philly will have the upper hand at home.
Expect Sean McVay to lean heavily on Kyren Williams and Blake Corum against a Bills defense that has been gashed for 274 rushing yards over its last two games.
Check out our full Bills vs. Rams predictions!
Buccaneers vs. Cowboys: 
Cowboys ❌
Not only was Jalon Daniels’ debut a complete disaster, but the Bucs’ defense is getting shredded, allowing the fourth-most yards per play heading into this TNF showdown.
Dak Prescott and the Cowboys’ offense are riding high after a thrilling win in Houston, and that momentum will carry over into a home win at Jerry World.
Check out our full Buccaneers vs. Cowboys predictions!
Eagles vs. Jaguars: 
Jaguars ✅
Jacksonville has plenty of experience playing overseas, and this London “home game” features a Jags team boasting an AFC-best +51 point differential.
With Philly’s offense banged up and DeVonta Smith, Dallas Goedert, and Saquon Barkley all potentially sidelined, I’ll take Jacksonville to get the job done across the pond.
Check out our full Eagles vs. Jaguars predictions!
Browns vs. Jets: 
Browns ❌
New York is coming off a messy loss in which it ran fewer plays than Chicago recorded first downs.
Now facing a red-hot Cleveland team coming off an extra three days of rest, expect the Browns to take care of business in front of the Dawg Pound.
Check out our full Browns vs. Jets predictions!
Bengals vs. Dolphins: 
Bengals ✅
Miami is averaging just 11.5 points per game heading into Week 5.
Cincy’s “much-improved” defense has been mostly fugazi so far, but Joe Burrow & Co. won’t need to be perfect to pull away in the Sunshine State.
Check out our full Bengals vs. Dolphins predictions!
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Raiders vs. Patriots: 
Raiders ❌
As Ed Scimia breaks down in his Raiders vs. Patriots early leans, Las Vegas has been the better team on both sides of the ball:
“While the Patriots have slightly better raw numbers, the advanced metrics favor the Raiders. Las Vegas ranks 12th in offensive EPA per play, compared to 21st for New England, and eighth in defensive EPA, compared to 12th for the Patriots.”
I like the Raiders to bounce back in Foxborough.
Check out our full Raiders vs. Patriots predictions!
Vikings vs. Saints: 
Vikings ✅
While Minnesota’s defense continues to bring the heat, the Vikings’ offense has flamed out for the most part under Kyler Murray.
Luckily, getting Justin Jefferson back against a Saints defense that ranks 30th in EPA per play is the perfect remedy for Murray & Co.
Minny improves to 5-0 in the Big Easy.
Check out our full Vikings vs. Saints predictions!
Texans vs. Titans: 
Texans ✅
If I wasn’t already out on Cam Ward, his latest postgame presser put the proverbial nail in the coffin.
The return of Nico Collins finally has Houston moving the ball with confidence, and the Texans will nab their first win of the season in Nashville.
Check out our full Texans vs. Titans predictions!
Giants vs. Commanders: 
Commanders ❌
Jameis Winston continues to be a turnover machine, while Washington is banking on Jayden Daniels returning under center for this NFC East rivalry.
The Commanders are 4-0 against the Giants dating back to 2024, and they’ll continue to own this matchup.
Check out our full Giants vs. Commanders predictions!
Colts vs. Steelers: 
Colts ❌
Indy’s defense has stepped up over the last few weeks, limiting opponents to just 2.85 yards per carry over that stretch.
With Aaron Rodgers and the Steelers’ offense remaining stagnant, give me Indy to make it three wins in a row.
Check out our full Colts vs. Steelers predictions!
Bears vs. Packers: 
Bears ❌
Chicago is coming off its best defensive performance of the season, with the Bears registering three sacks and seven QB hits while holding the Jets to 0-for-7 on third down.
Now facing a Green Bay team that nearly blew another double-digit lead (shocker, I know), expect Dennis Allen to blitz the hell out of Jordan Love and take advantage of a shaky Packers O-line.
Check out our full Bears vs. Packers predictions!
Broncos vs. Chargers: 
Chargers ❌
Bo Nix’s passing chart this season should alarm Broncos Country, and Denver has produced just 13 first-half points through four games.
With Pat Surtain II sidelined for this clash at SoFi, I’m buying low on the Chargers as a home dog.
Check out our full Broncos vs. Chargers predictions!
Lions vs. Cardinals: 
Lions ✅
Detroit’s defense can’t stop a nosebleed, but Jacoby Brissett isn’t exactly striking fear into anyone.
Arizona’s stop unit just gave up 36 points to Jameis Winston and the Giants, so I’ll take Detroit’s offense to do the heavy lifting (again) in the desert.
Check out our full Lions vs. Cardinals predictions!
49ers vs. Seahawks: 
49ers ✅
The loss of former OC Klint Kubiak has been evident for Seattle’s offense, particularly on third downs, where the Seahawks rank 31st in conversion rate. Meanwhile, Brock Purdy and the 49ers lead the league in that category.
With Sam Darnold seeing ghosts again, I’m rolling with the 49ers to exact some revenge in the PNW.
Check out our full 49ers vs. Seahawks predictions!
Odds are correct at the time of publishing and are subject to change.
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