Knicks vs. Timberwolves prediction, odds: Wednesday NBA picks from proven computer

NBA title contenders meet in the national spotlight when the Minnesota Timberwolves travel to take on the New York Knicks on Wednesday. Both teams are 4-3 this season, though New York is also 4-3 against the spread, while Minnesota is just 2-5 ATS. Anthony Edwards (hamstring), originally expected to be out for longer, has been upgraded to questionable for Minnesota. Karl-Anthony Towns (illness) is questionable for New York.

Tipoff from Madison Square Garden is set for 7:30 p.m. ET. New York is a 3-point favorite in the latest Knicks vs. Timberwolves odds, while the over/under is 227.5. Before making any Timberwolves vs. Knicks picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 3 of the 2025-26 NBA season on a sizzling 26-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Knicks vs. Timberwolves 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Timberwolves vs. Knicks:

Top Knicks vs. Timberwolves prop pick:

After 10,000 simulations, SportsLine’s model is projecting that Mikal Bridges goes Over 14.5 points, a prop that returns -128 (risk $128 to return $100). Bridges has cleared his points total in seven of his past 10 games when the Knicks were favored and playing a team with a winning record, which is the spot they are in on Wednesday.

His points prop line is down a bit after he’s scored just 10 points in each of his past two games. Zooming out a bit, however, he’s averaging 16.4 points per game this season, and he averaged 19 points per game during the first five games of the season.

Minnesota ranks 20th in the NBA in defensive efficiency, and the model is projecting that Bridges scores 17.1 points in the simulations, making it one of the highest-rated points prop picks for this matchup. See which team to back against the spread at SportsLine, and bet that prop here:

How to make Knicks vs. Timberwolves picks

SportsLine’s model has simulated Timberwolves vs. Knicks 10,000 times and is leaning Over the total, projecting 228 combined points. The model also says one side hits in nearly 60% of simulations. You can head to SportsLine to see the model’s NBA picks. 

So who wins Timberwolves vs. Knicks, and which side of the spread hits in nearly 60% of simulations? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.