Lakers vs. Thunder prediction, odds: NBA picks, best bets for Wednesday, Nov. 12

Western Conference powers meet in a spotlight matchup as the Oklahoma City Thunder host the Los Angles Lakers on Wednesday. The defending champions have stormed out to an 11-1 start this season, while L.A. is 8-3. The Lakers, however, have the better spread record at 8-3, with OKC at 7-5 ATS. LeBron James (sciatica) remains out for Los Angeles. OKC hasn’t released its injury report as it is on the second night of a back-to-back. Aaron Wiggins (adductor) and Jalen Williams (wrist) are among the six players the Thunder have ruled out. 

Tipoff is set for 9:30 p.m. ET at the Paycom Center. OKC is an 8-point home favorite in the latest Lakers vs. Thunder odds, while the over/under is 229.5. Before making an Thunder vs. Lakers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight seasons. The model enters Week 4 of the 2025-26 NBA season on a sizzling 26-13 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Lakers vs. Thunder 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several NBA odds and NBA betting lines for Thunder vs. Lakers:

How to make Lakers vs. Thunder picks

SportsLine’s model has simulated Lakers vs. Thunder 10,000 times and is going Over 229.5 combined points. These teams have trended to the Over all season. Los Angeles games have hit the Over nine times in 11 tries, while OKC is 4-1 to the Over when playing at home. The model likes the Over in nearly 60% of simulations in this matchup.

The model also says one side of the spread hits over 60% of the time. You can head to SportsLine to see the model’s NBA picks. 

So who wins Lakers vs. Thunder, and which side of the spread hits over 60% of the time? Visit SportsLine now to see which side of the spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.